production and quality control of 166ho-chitosan for therapeutic applications
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abstract
introduction: in this research, [166ho]holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. finally a ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed.methods: 166ho-chitosan complex was prepared using chitosan concentrations and 166hocl3 followed by intra-articular injection and biodistribution studies in wild-type rats including and excluding injected knee.results: the [166ho]holmium chitosan complex was prepared with high radiochemical yield (>95 %) in the optimized condition (35mg/3ml of chitosan in %1 acoh, ph. 3, >98%, itlc) was injected to wild-type rats followed by the biodistribution studies of the compound among the tissues excluding the injected knee data. intra-articular injection of [166ho]holmium chitosan complex to male wild-type rats and investigation of leakage of activity in the body showed that most of injected dose has remained in injection site 144 h after injection. conclusion: successful development and formulation of 166ho-chitosan kit is described. this kit has the potential for use in clinical setting namely for radiosynovectomy and cancer radiochemotherapy.
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Journal title:
iranian journal of nuclear medicinePublisher: tehran university of medical sciences
ISSN 1681-2824
volume 18
issue 2 2010
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